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KMID : 0357919860200040462
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Korean Journal of Pathology
1986 Volume.20 No. 4 p.462 ~ p.469
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A Study on the Typhoid Granuloma in the Bone Marrow Biopsy of Patients with Typhoid Fever
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Abstract
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To evaluate the appearance rate of typhoid granuloma, a clinical and histological study
was made on bone marrow smears or biopsies of 60 patients with proven typhoid fever.
The results were as follows:
1) Sixty cases consisted of 34 cases of bacteriologically proved group, 10 cases of
serologically proved group, and 16 cases of clinically suspected group. The positive
culture rate from bone marrow fluid was the highest (70.6%) among specimens although
it was obtained 1.6 days in average after the administration of antibiotics.
2) Fourth-eight cases of bone marrow smear revealed the M:E ratio of 3.93:1 in
average, mild myeloid hyperplasia and 50.5% of appearance rate of typhoid cells.
3) Fourth-nine cases of bone marrow biopsy revealed 8 cases of typhoid granuloma, all
of which belonged to the bacteriologically proved group. All these have no
pathognomonic morphologic features.
4) Fourty cases of bone marrow examination of patients with FUO except typhoid
fever revealed no typhoid cells in smear and 3 cases of granulomatous lesion from two
patients with miliary tuberculosis and one patient with Hodgkin's lymphoma.
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